|
KMID : 1009020110090020086
|
|
Clinical Psychopharmacology and Neuroscience
2011 Volume.9 No. 2 p.86 ~ p.90
|
|
|
Effects of Sinapic Acid of 4 Vessel Occlusion Model-Induced Ischemia and Cognitive Impairments in the Rat
|
|
Kim Young-Ock
Lee Sang-Won
Oh Myung-Sook
Lee Hee-Jae
|
|
|
Abstract
|
|
|
Objective : Sinapic acid (SA, Sinapine), small naturally occurring hydroxycinnamic acid, has a GABA(A) receptor agonistic property and free radical scavenging activity. We examined potential neuroprotective effects of sinapic acid (SA) using global cerebral ischemia animal model.
Methods : MTT assay was performed to determine cytotoxic effects of SA. To examine the neuroprotective effects of SA, SA was administrated for 14 d before 4-vessel occlusion. Also, to determine whether SA prevents cognitive impairment, Morris water maze was performed.
Results : In this study, the efficacy of SA for the prevention of neuronal damage and for the reduction of memory impairment was investigated.
Conclusion : The results indicate that SA confers significant neuroprotection especially for ischemic hippocampal neurons.
|
|
|
KEYWORD
|
|
|
Sinapic acid, Neuroprotection effect, Memory, Hippocampus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|